Detection of gastrointestinal cancer with CEA and anti-CEA. by Keith Richard Hine

Cover of: Detection of gastrointestinal cancer with CEA and anti-CEA. | Keith Richard Hine

Published by University of Birmingham in Birmingham .

Written in English

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Thesis (M.D.)- University of Birmingham, Dept of Immunology.

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Open LibraryOL13796374M

Download Detection of gastrointestinal cancer with CEA and anti-CEA.

A recombinant, proprietary bispecific T-cell engagers (BiTE) antibody directed against human carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. Anti-CEA BiTE monoclonal antibody MEDI possesses two antigen-recognition sites, one for CEA and one for the CD3 complex, a group of T cell surface glycoproteins that complex with the T cell receptor (TCR).

A radioimmunoconjugate comprised of a recombinant scFv dimer diabody of a monoclonal antibody against human carcinoembryonic antigen (CEA) labeled with iodine I (I) with potential radioimmunolocalization applications. The antibody moiety of iodine I anti-CEA recombinant diabody T binds to cells expressing CEA, selectively delivering I upon cellular internalization and.

Sep 21,  · PURPOSE To establish a sensitive assay for the specific detection of carcinoembryonic antigen (CEA)-expressing tumor cells in the bone marrow of patients with colorectal cancer and other CEA-positive carcinomas.

PATIENTS AND METHODS A CEA-specific nested reverse transcriptase (RT) polymerase chain reaction (PCR) assay was developed and optimized using limiting dilutions of a Cited by: Carcinoembryonic Antigen in the Management of Patients With Colorectal Cancer.

CEA, an oncofetal antigen, was first described by Gold and Freedman in CEA is a large family of 36 Detection of gastrointestinal cancer with CEA and anti-CEA.

book but related glycoproteins that are part of the immunoglobulin superfamily. Carcinoembryonic antigen (CEA) is a widely used tumor marker for diagnostic and therapeutic purposes in gastrointestinal, breast and lung cancer [].The normal range for CEA in an adult non- smoker is less than ng/mL and for a smoker less than ng/mL in human serum, but its level exceeds ng/mL upon development of certain cancers [].A rising CEA level indicates progression or Cited by: Download Citation | Fluorophore-Conjugated Chimeric Anti-CEA Antibodies for Fluorescence-Guided Surgery of Gastrointestinal (GI) Tumors | Negative surgical margins are necessary to prevent.

In the present chapter, we review the use of fluorophore-labeled anti-carcinoembryonic antigen (CEA) monoclonal antibodies for fluorescence-guided surgery (FGS) in nude mouse models of human colorectal and pancreatic cancer in order to achieve negative margins.

Anti-CEA was conjugated with fluorophores of visible and near-infrared Michael Bouvet, Robert M. Hoffman. F(ab’)2 fragments of an anti-CEA monoclonal antibody were radiolabelled with I and used to study eleven patients with various types of gastrointestinal carcinomas.

The antibody scans detected Author: A. Bamias, J. Sackier, H. Kalofonos, B. Dhokia, D. Snook, K. Bosslet, C. Wood, A. Epenetos. Mar 23,  · Radioiodinated anti-carcinoembryonic antigen (CEA) monoclonal antibody (MAb) NP-4 F(ab´)2 fragment (I/I/I-NP-4 F(ab´)2), which is formed by the conjugation of radioiodine with a murine anti-CEA MAb F(ab´)2 fragment, can be used for imaging and therapy of CEA-expressing cancers (1, 2).

I has a relatively long physical half-life (t½) of 60 days and a gamma energy that makes it Author: Kenneth T. Cheng. Elevation of the biliary CEA level in patients with liver metastases from colorectal carcinoma has been reported.

The aim of this study is to determine the potential value of biliary CEA assay in the early detection of liver by: Carcinoembryonic antigen (CEA), highly expressed in many cancer types, is an important target for cancer diagnosis and therapy.

Radionuclide-based imaging techniques (gamma camera, single photon. Abstract. We tested whether nuclear imaging with indium (In)-labeled murine monoclonal (MoAb) anticarcinoembryonic antigen (anti-CEA) ZCE antibody could detect recurrent disease in patients with a rising serum CEA level but negative findings for computed tomographic (CT) scans of the abdomen and pelvis, chest radiograph, and colonoscopy or barium enema.

Carcinoembryonic antigen (CEA) is an oncofoetal cell-surface glycoprotein that serves as an important tumor marker for colorectal and some other carcinomas. In this work, a CEA immunoassay using a surface plasmon resonance (SPR) biosensor has been developed. SPR could provide label-free, real-time detection with high sensitivity, though its ability to detect CEA in human serum was highly Cited by: A study was undertaken to test whether indium (In)-labeled anti-carcinoembryonic antigen (CEA) (type ZCE ) monoclonal intact antibody (MoAb) would concentrate in primary lung cancer enabling its detection and localization by scintigraphy.

Apr 02,  · Anti-CEACAM antibody 6G5j binds multiple CEACAMs which may lead to improved detection of tumor margins for tumors and metastases that have variable expression of CEA and other CEACAMs. 6G5j mAb may be useful for colon cancer detection for pre-surgical diagnosis and fluorescence-guided surgery.

Jan 22,  · AbstractPlasmonic sensing has a great potential in the portable detection of human tumor markers, among which the carcinoembryonic antigen (CEA) is one of the most widely used in clinical medicine.

Traditional plasmonic and non-plasmonic methods for CEA biosensing are still not suitable for the fast developing era of Internet of things. In this study, we build up a cost-effective plasmonic Cited by: 7. Dec 11,  · Other cross-reactive, but genetically distinct, CEA variants have been identified, including nonspecific cross-reactive antigen (NCA) and meconium antigen (MA).

Radiolabeled MAbs have been developed for both the diagnosis and treatment of tumors. IMMU-4 was developed from the anti-CEA NP-4 MAb (2, 5, 6). Aug 25,  · Carcinoembryonic antigen (CEA) is overexpressed in a large number of gastrointestinal, lung, and breast cancers.

Clinical trials have established treatment protocols using viral vectors to immunize patients to CEA without producing deleterious autoimmune by: 3. Meet Lawrence C.

Swayne, MD Nuclear Medicine Specialist in Parsippany. Lawrence C. Swayne is Board Certified by the American Board of Radiology. He is the Vice-Chairman of the Department of Radiology at Morristown Medical Center and has been a member since Nov 26,  · Anatomo-Pathological Analysis of Human Tumors with 3 Anti CEA (Carcino-Embryonic Antigen) Monoclonal Antibodies Detection of Carcinoembryonic Antigen in Cancer Serum by Two-Dimensional Gel Electrophoresis Prognostic Significance of CEA in Gastrointestinal Cancer In Vivo Correlation of Circulating CEA and Tumor Volume in Patients with Solitary Book Edition: 1.

Jul 13,  · Preparation of a high specific activity In-labeled anti-CEA monoclonal antibody. An improved method for synthesis of DTPA-conjugates. Cancer Research6. Philben VJ, Jakowatz JG, Beatty BG, Vlahos WG, Paxton RJ, Williams LE, Shively JE, Beatty JD.

In-labeled anti-CEA monoclonal antibody. Fishpond Thailand, Clinical Use of Antibodies: Tumours, infection, infarction, rejection and in the diagnosis of AIDS (Developments in Nuclear Medicine) by Richard P Baum (Edited) P H Cox (Edited)Buy.

Books online: Clinical Use of Antibodies: Tumours, infection, infarction, rejection and in the diagnosis of AIDS (Developments in Nuclear Medicine),tytan-team.comd: Springer.

Nov 01,  · • The present study was undertaken to determine whether an anti—carcinoembryonic antigen (CEA) monoclonal antibody (MAB), labeled with the potent beta emitter yttrium 90, could alter the growth of diffuse intraperitoneal carcinomatosis of colon Cited by: Surface enhanced Raman scattering detection of cancer biomarkers with bifunctional banocomposite probes.

Anal Chem. ; Lin G, Feng S, Pan J, Chen Y, Lin J, Chen G, Xie S, Zeng H, Chen R. Colorectal cancer detection by gold nanoparticle based surface-enhanced Raman spectroscopy of blood serum and statistical analysis. Methods are provided for using radiolabeled antibody fragments specific to tumor-associated markers for detection, localization and therapy of tumors.

Mixtures of labeled fragments with varied specificity or multivalent hybrid fragments permit detection and localization of more than one tumor or tumor cell type. Antibodies and injectable compositions for use in the methods of the invention are. May 25,  · Methods are provided for using radiolabeled antibody fragments specific to tumor-associated markers for detection, localization and therapy of tumors.

Mixtures of labeled fragments with varied specificity or multivalent hybrid fragments permit detection and localization of more than one tumor or tumor cell type. Note: Citations are based on reference standards.

However, formatting rules can vary widely between applications and fields of interest or study. The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied. Nov 26,  · Purchase Protides of the Biological Fluids, Volume 32 - 1st Edition.

Print Book & E-Book. ISBNTissue Distribution of Radiolabeled Anti-CEA Monoclonal Antibodies in Man Immunoscintigraphy Using F(Ab')2 Fragments The Value of Centocor CA TM or Gastrointestinal Cancer Associated Antigen (GICA) in the Book Edition: 1.

Cancer Detection by Immunoscintigraphy, Selection, and Clinical Application of Monoclonal Anti-CEA Antibodies and Their F (ab?)2 or Fab Fragments.- Proposal for Staging Liver Metastases.- A Clinical Trial by the Gastrointestinal Tract Cancer Group of the European Organization for Research and Treatment of Cancer.- Indications and.

Apr 24,  · CEA is considered to be primarily a cell-surface antigen, as reported by Heyderman, Scand. Immunol., 8, Suppl. 8, (), and many others. However, tumor localization using antibodies to cell surface antigens has hitherto been limited to anti-CEA antibodies.

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The quality control and clinical testing of radiolabelled antibodies.- 4. Clinical utility of radiolabelled monoclonal antibodies in the management of gastrointestinal cancer.- 5. Use of I radiolabelled F(AB')2 fragments of anti-CEA monoclonal antibody for the detection of primary and metastatic gastrointestinal carcinomas.- 6.

Renal cell carcinoma is characterised by negativity for Hep Par 1 and CEA expression (by polyclonal anti-CEA antibody). Unfortunately, the rate of RCC expression decreases from % in primary clear cell renal carcinoma and % in papillary renal cell cancer to 20% in metastatic renal cell by: 2.

Sep 21,  · The target antigen used in this study is carcinoembryonic antigen (CEA), which has been implicated in the metastatic process. 1 Although CEA is expressed in fetal gastrointestinal tissues and normal adult colonic tissue, it is overexpressed in the vast majority of human colorectal, gastric, and pancreatic cancers, in approximately 70% of non Cited by: Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+).

Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and Abeomics. Jan 18,  · Radiolabeled Monoclonal Antibodies for Imaging and Therapy by Suresh C.

Srivastava,available at Book Depository with free delivery worldwide. Authored by leaders in the development of fluorescent methods worldwide, Fluorescence Imaging for Surgeons: Concepts and Applications will have an impact on numerous medical specialists including general surgeons, colorectal and minimally-invasive surgeons and surgical oncologists.

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It was at Frankfurt/Mainin that Paul Ehrlich first expounded his famous "site-chain theory" -which described the basic immunological principal of antibody-antigen interactio- on the occasion of the opening of the Institute for Experimental Therapeutics (which was later named after him). Nearly.

The estimated frequency of detection of anti-carcinoembryonic antigen (CEA) anti-survivin, anti-mucin, and anti-livin autoantibodies is 46–56, 40, 75 and 50%, respectively, as anti-CEA is Author: Mila Dimitrova Kovacheva-Slavova, Todor Asenov Angelov, Hristo Yankov Valkov, Hristo Ilianov Iliev.

Jaffer A. Ajani, M.D., Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine Imaging with indiumlabeled anticarcinoembryonic antigen monoclonal antibody ZCE of recurrent colorectal or carcinoembryonic antigen-producing cancer in patients with rising serum carcinoembryonic antigen levels and occult metastases."A pilot study examining the feasibility of using immunolymphoscintigraphy to detect and quantify breast cancer lymph node metastases: staging the axilla preoperatively using the Tc 99m labeled Fab' fragment of the anti CEA antibody Immu 4" January January $75, University of South Florida.

Principal Investigator.In Vivo Kinetics of Radiolabeled Monoclonal Anti-CEA Antibodies in Animal Models J Nucl Med 26 Atlas of Nuclear Medicine Artifacts and Variants: U.

Yun Ryo, C. Bekerman, S. M. Pinsky, Chicago Year Book Medical Publishers, Inc.,pp, $ J Nucl Med Recent Advances in Imaging Steroid Hormone Receptors in Breast Cancer.

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